The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa

Isaac Okyere; Sanjeev Singh; Perditer Okyere; Baffoe Gyan; Nana Addo Boateng; Enoch Akowuah

doi:doi:10.11648/j.js.20200804.17

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The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa

Isaac Okyere, Sanjeev Singh, Perditer Okyere, Baffoe Gyan, Nana Addo Boateng, Enoch Akowuah

Published in Journal of Surgery (Volume 8, Issue 4)

Received: 3 July 2020 Accepted: 15 July 2020 Published: 4 August 2020

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Abstract

The durability of artificial bioprosthestic or tissue heart valves is limited by structural valve deterioration (SVD) due to long-term calcification especially in young patients and in Africa. A novel bioprosthestic valve, the Resilia Inspiris Aortic Tissue Valve has been developed which, in preclinical studies, has shown reduced calcification thus improving durability. The Inspiris Resilia Aortic Valve is a stented tri-leaflet valve made from bovine pericardial tissue. The tissue is created by treating bovine pericardial tissue with Edwards Integrity Preservation. It incorporates a stable capping anticalcification process, which blocks residual aldehyde groups known to bind with calcium. Tissue preservation with glycerol allows the valve to be stored without a traditional liquid-based solution, such as glutaraldehyde. Therefore, the valve is stored under dry packaging conditions and consequently does not require rinsing prior to implantation. The novel tissue preservation technology significantly improves hemodynamic and anticalcification properties compared with the standard artificial bioprosthestic aortic valve, the Perimount tissue valve. The experience of the implantation of this valve in Africa is limited for there seems to be no published experience of the behaviour of the implantation of this special long lasting bioprosthestic valve in Africa and therefore the purpose of this paper is to share our initial experience of the first successful implantation of this Inspiris Resilia Aortic Valve^™ in Ghana, Africa. The implantation was done in a 57-year-old patient who presented with symptomatic moderate to severe aortic valve regurgitation with adequate left ventricular systolic function. He has been followed-up for a year now with well-healed wounds and a transthoracic echocardiography revealing a well-seated valve with no regurgitant flow or paravalvular leak. This is the first report describing the use of the new Inspiris Resilia Aortic valve which has increased durability and does not require anticoagulation in Africa as far as we know.

Published in	Journal of Surgery (Volume 8, Issue 4)
DOI	10.11648/j.js.20200804.17
Page(s)	136-139
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Aortic Valve, Inspiris Resilia Aortic Valve, Open Heart Surgery, Bioprosthestic Valve

References

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[2]	Rajashekar P. Development of mechanical heart valves - an inspiring tale. J Pract Cardiovasc Sci. 2015; 1 (3): 289.
[3]	Russo M, Taramasso M, Guidotti A, Pozzoli A, Nietilspach F. The evolution of surgical valves. Cardiovasc Med. 2017; 20 (12): 285–92.
[4]	DeWall RA, Qasim N, Carr L. Evolution of mechanical heart valves. Ann Thorac Surg. 2000; 69 (5): 1612–21.
[5]	Vlahakes GJ. Mechanical heart valves: The test of time... Circulation. 2007; 116 (16): 1759–60.
[6]	Spinner EM. The History of Heart valves: an industry perspective. Front Eng Reports Leading-Edge Eng from 2015 Symp [Internet]. 2015; Spring 201: 25–30. Available from: http://www.nap.edu/catalog/21825.
[7]	Singhal P, Luk A, Butany J. Bioprosthetic Heart Valves: Impact of Implantation on Biomaterials. ISRN Biomater. 2013; 2013: 1–14.
[8]	Li KYC. Bioprosthetic Heart Valves: Upgrading a 50-Year Old Technology. Front Cardiovasc Med. 2019; 6 (April): 1–6.
[9]	Choudhary SK, Talwar S, Airan B. Choice of prosthetic heart valve in a developing country. Heart Asia. 2016; 8 (1): 65–72.
[10]	Puskas JD, Bavaria JE, Svensson LG, Blackstone EH, Griffith B, Gammie JS, et al. The COMMENCE trial: 2-year outcomes with an aortic bioprosthesis with RESILIA tissue. Eur J Cardio-thoracic Surg. 2017; 52 (3): 432–9.
[11]	Bartus K, Litwinowicz R, Bilewska A, Stapor M, Bochenek M, Rozanski J, et al. Intermediate-term outcomes after aortic valve replacement with a novel RESILIA^TM tissue bioprosthesis. J Thorac Dis. 2019; 11 (7): 3039–46.
[12]	Bartuś K, Litwinowicz R, Kuśmierczyk M, Bilewska A, Bochenek M, Stąpór M, et al. Primary safety and effectiveness feasibility study after surgical aortic valve replacement with a new generation bioprosthesis: One-year outcomes. Kardiol Pol. 2018; 76 (3): 618–24.

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APA Style

Isaac Okyere, Sanjeev Singh, Perditer Okyere, Baffoe Gyan, Nana Addo Boateng, et al. (2020). The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa. Journal of Surgery, 8(4), 136-139. https://doi.org/10.11648/j.js.20200804.17

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ACS Style

Isaac Okyere; Sanjeev Singh; Perditer Okyere; Baffoe Gyan; Nana Addo Boateng, et al. The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa. J. Surg. 2020, 8(4), 136-139. doi: 10.11648/j.js.20200804.17

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AMA Style

Isaac Okyere, Sanjeev Singh, Perditer Okyere, Baffoe Gyan, Nana Addo Boateng, et al. The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa. J Surg. 2020;8(4):136-139. doi: 10.11648/j.js.20200804.17

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@article{10.11648/j.js.20200804.17,
  author = {Isaac Okyere and Sanjeev Singh and Perditer Okyere and Baffoe Gyan and Nana Addo Boateng and Enoch Akowuah},
  title = {The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa},
  journal = {Journal of Surgery},
  volume = {8},
  number = {4},
  pages = {136-139},
  doi = {10.11648/j.js.20200804.17},
  url = {https://doi.org/10.11648/j.js.20200804.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20200804.17},
  abstract = {The durability of artificial bioprosthestic or tissue heart valves is limited by structural valve deterioration (SVD) due to long-term calcification especially in young patients and in Africa. A novel bioprosthestic valve, the Resilia Inspiris Aortic Tissue Valve has been developed which, in preclinical studies, has shown reduced calcification thus improving durability. The Inspiris Resilia Aortic Valve is a stented tri-leaflet valve made from bovine pericardial tissue. The tissue is created by treating bovine pericardial tissue with Edwards Integrity Preservation. It incorporates a stable capping anticalcification process, which blocks residual aldehyde groups known to bind with calcium. Tissue preservation with glycerol allows the valve to be stored without a traditional liquid-based solution, such as glutaraldehyde. Therefore, the valve is stored under dry packaging conditions and consequently does not require rinsing prior to implantation. The novel tissue preservation technology significantly improves hemodynamic and anticalcification properties compared with the standard artificial bioprosthestic aortic valve, the Perimount tissue valve. The experience of the implantation of this valve in Africa is limited for there seems to be no published experience of the behaviour of the implantation of this special long lasting bioprosthestic valve in Africa and therefore the purpose of this paper is to share our initial experience of the first successful implantation of this Inspiris Resilia Aortic Valve™ in Ghana, Africa. The implantation was done in a 57-year-old patient who presented with symptomatic moderate to severe aortic valve regurgitation with adequate left ventricular systolic function. He has been followed-up for a year now with well-healed wounds and a transthoracic echocardiography revealing a well-seated valve with no regurgitant flow or paravalvular leak. This is the first report describing the use of the new Inspiris Resilia Aortic valve which has increased durability and does not require anticoagulation in Africa as far as we know.},
 year = {2020}
}

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TY  - JOUR
T1  - The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa
AU  - Isaac Okyere
AU  - Sanjeev Singh
AU  - Perditer Okyere
AU  - Baffoe Gyan
AU  - Nana Addo Boateng
AU  - Enoch Akowuah
Y1  - 2020/08/04
PY  - 2020
N1  - https://doi.org/10.11648/j.js.20200804.17
DO  - 10.11648/j.js.20200804.17
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 136
EP  - 139
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20200804.17
AB  - The durability of artificial bioprosthestic or tissue heart valves is limited by structural valve deterioration (SVD) due to long-term calcification especially in young patients and in Africa. A novel bioprosthestic valve, the Resilia Inspiris Aortic Tissue Valve has been developed which, in preclinical studies, has shown reduced calcification thus improving durability. The Inspiris Resilia Aortic Valve is a stented tri-leaflet valve made from bovine pericardial tissue. The tissue is created by treating bovine pericardial tissue with Edwards Integrity Preservation. It incorporates a stable capping anticalcification process, which blocks residual aldehyde groups known to bind with calcium. Tissue preservation with glycerol allows the valve to be stored without a traditional liquid-based solution, such as glutaraldehyde. Therefore, the valve is stored under dry packaging conditions and consequently does not require rinsing prior to implantation. The novel tissue preservation technology significantly improves hemodynamic and anticalcification properties compared with the standard artificial bioprosthestic aortic valve, the Perimount tissue valve. The experience of the implantation of this valve in Africa is limited for there seems to be no published experience of the behaviour of the implantation of this special long lasting bioprosthestic valve in Africa and therefore the purpose of this paper is to share our initial experience of the first successful implantation of this Inspiris Resilia Aortic Valve™ in Ghana, Africa. The implantation was done in a 57-year-old patient who presented with symptomatic moderate to severe aortic valve regurgitation with adequate left ventricular systolic function. He has been followed-up for a year now with well-healed wounds and a transthoracic echocardiography revealing a well-seated valve with no regurgitant flow or paravalvular leak. This is the first report describing the use of the new Inspiris Resilia Aortic valve which has increased durability and does not require anticoagulation in Africa as far as we know.
VL  - 8
IS  - 4
ER  -

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Author Information

Isaac Okyere

Cardiovascular and Thoracic Surgery Unit, Directorate of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana
Sanjeev Singh

School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Perditer Okyere

School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Baffoe Gyan

The National Cardiothoracic Centre, Korle-Bu Teaching Hospital, Accra, Ghana
Nana Addo Boateng

Directorate of Anaesthesia and Intensive Care, Komfo Anokye Teaching Hospital, Kumasi, Ghana
Enoch Akowuah

James Cook University Hospital and South Tees NHS Foundation Trust, Middlesbrough, United Kingdom

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Plain Text BibTeX RIS

APA Style

Isaac Okyere, Sanjeev Singh, Perditer Okyere, Baffoe Gyan, Nana Addo Boateng, et al. (2020). The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa. Journal of Surgery, 8(4), 136-139. https://doi.org/10.11648/j.js.20200804.17

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ACS Style

Isaac Okyere; Sanjeev Singh; Perditer Okyere; Baffoe Gyan; Nana Addo Boateng, et al. The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa. J. Surg. 2020, 8(4), 136-139. doi: 10.11648/j.js.20200804.17

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AMA Style

Isaac Okyere, Sanjeev Singh, Perditer Okyere, Baffoe Gyan, Nana Addo Boateng, et al. The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa. J Surg. 2020;8(4):136-139. doi: 10.11648/j.js.20200804.17

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@article{10.11648/j.js.20200804.17,
  author = {Isaac Okyere and Sanjeev Singh and Perditer Okyere and Baffoe Gyan and Nana Addo Boateng and Enoch Akowuah},
  title = {The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa},
  journal = {Journal of Surgery},
  volume = {8},
  number = {4},
  pages = {136-139},
  doi = {10.11648/j.js.20200804.17},
  url = {https://doi.org/10.11648/j.js.20200804.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20200804.17},
  abstract = {The durability of artificial bioprosthestic or tissue heart valves is limited by structural valve deterioration (SVD) due to long-term calcification especially in young patients and in Africa. A novel bioprosthestic valve, the Resilia Inspiris Aortic Tissue Valve has been developed which, in preclinical studies, has shown reduced calcification thus improving durability. The Inspiris Resilia Aortic Valve is a stented tri-leaflet valve made from bovine pericardial tissue. The tissue is created by treating bovine pericardial tissue with Edwards Integrity Preservation. It incorporates a stable capping anticalcification process, which blocks residual aldehyde groups known to bind with calcium. Tissue preservation with glycerol allows the valve to be stored without a traditional liquid-based solution, such as glutaraldehyde. Therefore, the valve is stored under dry packaging conditions and consequently does not require rinsing prior to implantation. The novel tissue preservation technology significantly improves hemodynamic and anticalcification properties compared with the standard artificial bioprosthestic aortic valve, the Perimount tissue valve. The experience of the implantation of this valve in Africa is limited for there seems to be no published experience of the behaviour of the implantation of this special long lasting bioprosthestic valve in Africa and therefore the purpose of this paper is to share our initial experience of the first successful implantation of this Inspiris Resilia Aortic Valve™ in Ghana, Africa. The implantation was done in a 57-year-old patient who presented with symptomatic moderate to severe aortic valve regurgitation with adequate left ventricular systolic function. He has been followed-up for a year now with well-healed wounds and a transthoracic echocardiography revealing a well-seated valve with no regurgitant flow or paravalvular leak. This is the first report describing the use of the new Inspiris Resilia Aortic valve which has increased durability and does not require anticoagulation in Africa as far as we know.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The First Implantation of the Novel Biological Heart Valve, the Inspiris Resilia Aortic Tissue Valve in Africa
AU  - Isaac Okyere
AU  - Sanjeev Singh
AU  - Perditer Okyere
AU  - Baffoe Gyan
AU  - Nana Addo Boateng
AU  - Enoch Akowuah
Y1  - 2020/08/04
PY  - 2020
N1  - https://doi.org/10.11648/j.js.20200804.17
DO  - 10.11648/j.js.20200804.17
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 136
EP  - 139
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20200804.17
AB  - The durability of artificial bioprosthestic or tissue heart valves is limited by structural valve deterioration (SVD) due to long-term calcification especially in young patients and in Africa. A novel bioprosthestic valve, the Resilia Inspiris Aortic Tissue Valve has been developed which, in preclinical studies, has shown reduced calcification thus improving durability. The Inspiris Resilia Aortic Valve is a stented tri-leaflet valve made from bovine pericardial tissue. The tissue is created by treating bovine pericardial tissue with Edwards Integrity Preservation. It incorporates a stable capping anticalcification process, which blocks residual aldehyde groups known to bind with calcium. Tissue preservation with glycerol allows the valve to be stored without a traditional liquid-based solution, such as glutaraldehyde. Therefore, the valve is stored under dry packaging conditions and consequently does not require rinsing prior to implantation. The novel tissue preservation technology significantly improves hemodynamic and anticalcification properties compared with the standard artificial bioprosthestic aortic valve, the Perimount tissue valve. The experience of the implantation of this valve in Africa is limited for there seems to be no published experience of the behaviour of the implantation of this special long lasting bioprosthestic valve in Africa and therefore the purpose of this paper is to share our initial experience of the first successful implantation of this Inspiris Resilia Aortic Valve™ in Ghana, Africa. The implantation was done in a 57-year-old patient who presented with symptomatic moderate to severe aortic valve regurgitation with adequate left ventricular systolic function. He has been followed-up for a year now with well-healed wounds and a transthoracic echocardiography revealing a well-seated valve with no regurgitant flow or paravalvular leak. This is the first report describing the use of the new Inspiris Resilia Aortic valve which has increased durability and does not require anticoagulation in Africa as far as we know.
VL  - 8
IS  - 4
ER  -

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